A recent Lancet article (12th February 2015) suggests that use of hormone replacement therapy may be associated with a slight risk in the development of ovarian cancer. While there may be a link between the development of ovarian cancer and hormone replacement therapy, the study does not confirm that H.R.T. produces ovarian cancer. The increased risk of developing ovarian cancer was 1 case per 1000 women, using hormone replacement therapy for 5 years, from around the age of 50. This of course needs to be balanced against the advantages of hormone replacement therapy. This is a matter which every individual patient should discuss with their doctor.